Background: Open heart surgery is one of the most important procedures that can resolve many cardiac problems. The most important of which are myocardial revascularization, valve replacement or repair of congenital or acquired structural abnormalities, exercise therapy play vital role in preventing the complication after cardiac surgery and other type of surgery especially pulmonary complication. The aim of this study is: To investigate effects of early resistance exercises guidelines on pulmonary function measures of patients with open heart surgery. Research design: A quasi-experimental design was utilized in the present study. The study was carried out at the Cardio Thoracic intensive care unit at South valley University Hospital. A convenient sample of 60 adult p.ts with open heart surgery from both sex assigned in to equal groups (control and study groups). resistance exercise apply 30 minutes, twice a day in the intensive care unit (ICU) until hospital discharge are done through using the three tools(patient assessment sheet, pulmonary function measures and Borg scale. Results: It was revealed that there was an obvious increase in the pulmonary function measures of patients with open heart surgery in post-operative phase compared with preoperative phase, with a very highly significant difference (p < 0.001). Conclusion: The resistance exercise guidelines had a significant impact on Pulmonary Function Measures of Patients with open heart surgery. Recommendations: A resistance exercise guidelines should be planned and offered on regular basis for patients undergoing cardiac surgery.