Background Patients with Acute myeloid leukemia are at risk of bleeding that may cause life-threatening and death Aim: To investigate the effect of implementing nursing instructions on minimize bleeding among patients with Acute Myeloid Leukemia. Study design: Quasi experimental research design was utilized in this study. Setting: The study was conducted in the critical care unit at south Egypt cancer institute at Assiut University hospital. Sample: A convenient sample of 60 adult patients divided randomly into (30 study and 30 control) groups. Tools: Two tools used for data collection, tool (I);An interview questionnaire, tool (II); assessment of bleeding tendency. Results: There was a statistical difference between study and control group regarding whole blood and amount of blood loss according to class of hemorrhagic Shock in addition this amount decreased after implementation of nursing instructions at 3rd and 5th day with P.value (0.008). Conclusion: This study confirmed our hypothesis that implementing of nursing instructions on the patients with acute myeloid leukemia leading to minimize bleeding. Recommendation: Continued nursing instructions at critical care units should be organized within south Egypt cancer institute.