Background: Emergency nurses play a vital role in the response phase of disaster including immediate and acute care offered to victims during disasters, such as conducting triage. Aim of the study: To assess emergency nurses response toward caring of victims during disasters. Subject and Method: Purposive sample of 200 nurses working in the emergency departments at Assiut University Hospital and The ministry of Health Hospitals within 6 months period. The tool of data collection was the disaster response questionnaire. Results: Finding of the study revealed that less than half of studied nurses (45,5%) had a poor level of knowledge regarding the disaster, response, education and training. Conclusion: Emergency nurses had poor level of knowledge regarding disaster, response, education and training. There was a statistical significant difference between knowledge of studied nurses in both hospital nurses group with (P. value = <0.001).While the third of studied nurses had a diploma in nursing and had a poor level of knowledge regarding care of victims during disasters. Recommendations: In-service training and education related to disaster management is required for all nurses' especially emergency nurses and should be tailored to the local needs and their actual competences.