Background: Nurse had vital role in implementing safety measures for patient connected to mechanical ventilator in critically ill patient. Aim of the study: was to assess nursing practice regarding safety measures on mechanically ventilated patients Research design: A descriptive research design was utilized in this study, the study was conducted in the intensive coronary care units at Assuit university heart hospital. A convenient sample: All available nurses 30 of nursing staff that working in mentioned setting. Tools: Two tools: questionnaire and observational checklist. Results: More than half of nurses were in age group less than 25 years. Concerning their educational level, 53.3% of the nurse held nursing institute. 60.0% of nurse had work experience less than 5 years. Total nurses level of practice was found that three of fifth of nurses 60.0% were low, 30.0 % of them were moderate and 10.0% were high. Conclusion: The general score of nurses complete nursing practice regarding safety measures on mechanical ventilation was to be low practice. Recommendations: Nurses need in –service training programs, periodic monitoring of nurses practices and effective training for new nurses.