Background: Systemic Lupus Erythematous (SLE) is a prototypical chronic multi organ autoimmune disorder that can lead to significant burden of disease and loss of life expectancy.Aims: to assess quality of life and disease activity of patients with Systemic Lupus Erythematous (SLE) and (SLE) Design: Descriptive research design was utilized in this study. Setting: The study was conducted in Rheumatology and Rehabilitation department at Assiut University Hospital. Sample: A 60 adult patients with (SLE) from both sexes aged among (18-65) years were recruited. Tools: Patient demographic and medical sheet, Systemic Lupus Erythematous disease activity (SLEDAI) scale and Short Form Health Survey 36 (SF-36) scale. Results: The majority of patients (86.7%) have aged between 18-35 years, females and married. The highest percentage of patients' disease activity were between mild and moderate disease activity with percentage (40.0% and 30.0% respectively) As regard quality of life domains (physical functioning, energy/fatigue, pain and general health) of studied group were less than half level of functioning Conclusions: the majority of patients' disease activity were between mild and moderate disease activity with decrease in quality of life Recommendation: Increase SLE patients awareness about the importance of periodic check up to prevent developing any complication related to the disease for enhancing their quality of life.