Aims: To assess the patient's knowledge about total hip replacement (THR) and exercises, designing educational nursing program for patients undergoing THR, and to assess the effect of educational nursing program on patients knowledge; Research design: Quasi-experimental design was utilized in this study; Setting: Orthopedic surgery department and outpatient clinic at Red Crescent Hospital - Cairo; Sample: 60 adult patients, their age between 18 – 65 years, both males and females. Divided into two groups (study group 30 and control group 30). The study group was received educational nursing program, while the control group was received routine hospital care; Tools: A structured interview questionnaire sheet it consists of two parts; Results: two thirds of the patients were in age group between 50-60 years (63.3%, 66.7% respectively) mean ±SD were (51.7 ± 6.2 and 52.6±6.6 respectively) and two thirds of the patients were females in both study and control group (66.7%, 63.3% respectively). There were statistical significant difference between study and control groups post and follow up in all items of knowledge P˂0.001 except definition of THR P˃0.005 in follow up phases. Conclusions: There was statistical significant improvement of knowledge in patients who received the educational nursing program than those patients who didn't receive the program. Recommendations: Discharge planning and teaching booklet for patients, using illustrated pamphlets by images should be available for those patients who cannot read and write.