Abstract Background: Researches has failed to incorporate the challenges facing male nursing students.  Therefore; this study Aimed at assessing the frustration facing male students in maternity curriculum and their life satisfaction. An exploratory descriptive Research Design was utilized. The Setting was Faculty of Nursing, Assiut University- Egypt.. Subjects was a convenient sample of all male nursing students who studied & recently passed Maternity Curriculum; a total of 162 students were recruited. Tools for data collection included; structured interview questionnaire; Frustration scale and Life satisfaction scale. The duration for data collection lasted for 6 months precisely from January to June 2016.  Results of this study revealed that, the mean age of participant students was 21.31years. There was a highly significance reversible correlation between frustration level and general feeling of satisfaction. Also high frustration level associated with low level of satisfaction. This study Concluded that, the level of frustration strongly correlated with level of satisfaction. This study Recommended depth orientation before starting maternity curriculum, workshop to discuss challenges & consernes with male students,future researches on enrollment, frustration, satisfaction and perception of male nursing students and the importance of further researches in this field with comparison between both sexes.