Background: Women with breast cancer require information to help them manage their illness, it assists patients in making treatment decisions and managing immediate effects of treatment. Aim: To identify informational needs among women with newly diagnosed breast cancer and to design a suggested nursing guidelines. Setting: This study was conducted at the outpatient clinic of Sohag Oncology Institute and Sohag University Hospital. Sample: A conveniente sample of (100) adult female patients diagnosed with breast cancer undergoing breast surgery, radiotherapy or chemotherapy the age of patient ranged between (18-65) years old during period of 6 months. Tools: The tools were used for data collection included: An interview questionnaire, Toronto informational needs questionnaire of breast cancer. The suggested nursing guidelines was developed by the researcher. Results: The present study revealed that about (83%) of the studied patients had unsatisfactory level of knowledge regarding breast cancer. There was a statistically significant difference among chemotherapy & surgery group between total information needs and educational level.Conclusion: Women with breast cancer lack information especially about their disease, treatments and examinations they are undergoing. Recommendations: Establishment of specialized resource centers in different governerates of Egypt,rural and urban areas for meeting informational needs among women with newly diagnosed breast cancer.