Background: Male infertility is a common and severe health problem. Infertility not only affects one's ability to have children, but also has emotional, psychological, family, and societal effects. Aim of the study: to assess knowledge and attitude about infertility among infertile males.Methods: Cross-sectional research design was used in the study. (Setting) The present study was conducted at outpatient's clinic of dermatology and andrology department at Main Assiut University Hospital. The sample of this study consisted of 200 infertile male who had come to outpatient's clinic of dermatology and andrology department Tools was utilized for data collection were infertile male knowledge and attitude questionnaire sheet. The results show that generally poor level of knowledge (62%) and a negative attitude (65.5%) toward male infertility. There were statistically significant differences between personal characteristics of infertile male and their knowledge and attitudes regarding male infertility. Conclusion: The sample study of the infertile male had poor knowledge about male infertility and had a negative attitude toward male infertility. Recommendations: Health education for males about infertility. Increase public awareness about infertility through mass media.