Background: Research on nursing students showed that adopting self-directive learning of effort, time, and study environment can positively influence academic achievements for undergraduate students and use of self-learning packages. Aim of the study: Identifying factors that affect the using of self-directive learning among technical nurses' students in maternal & neonatal course Nursing Institute Fayoum University. Subject and methods: A descriptive study design was used to achieve the aim of the study. Included two groups; the 1st included 50 students & the 2nd 7 instructors during the 1st semester (October 2013/2014) from the pre-mentioned institute. Sample type: a convenient sample Tools: Interviewing questionnaire sheet to assess samples characteristics'& Opinionnaire sheet to assess the students' and instructors'. Opinions regarding factors affecting using of self-directive learning. Results: all students and instructors have past knowledge and practice about the computer use, student's views includes 98% student's language abilities and 96% clarity aim of the package& clarity content are the most of important factors contribute to use self-directed learning, 100% of students recommended providing suitable time for package and100% of instructors recommended suitable time for package, procedures should be clear and interesting images, Institution administration, Program innovation, and availability of resources. Conclusion: Clarity of the topics, organization, student language level, teacher characteristics, academic abilities and availability of resources among factors can facilitating or hindering the use of self-directive learning approach. Recommendations: Nursing institution administrators must support teacher and student by creating an environment conducive to implement self-directive learning.