Palliative care is care for patients with serious illness that focuses on relieving suffering and improving quality of life for patients and their families. Aim of the study: assess knowledge and practices of critical care nurses regarding palliative care of cancer patients, and suggest nursing guidelines booklet about palliative care for cancer patients. Sample: The study subjects consist of all available nursing staff (60) at medical intensive care unit (30), surgical intensive care (30) unit. Research design: Descriptive exploratory research design was used to conduct this study. Tools: Two tools were included nurses' structured interview sheet, and nurse observational checklist sheet. Results: the majority of studied nurses (97%) had unsatisfactory knowledge scores regarding palliative care with Mean+SD 21 + 3.2., more than half of studied nurses (63.3%) had unsatisfactory level of practice regarding palliative care with Mean+SD 19.8 + 2.7., there were no statistically significant relation between practices and knowledge. Conclusion: The majority of studied nurses (97%) had unsatisfactory knowledge, as well more than half (63%) of studied nurses had unsatisfactory level of practices regarding palliative care of patients with cancer Recommendations: Enrichment of all nurses about knowledge and practices related to palliative care will be helpful to achieve quality of life, and reading nursing guidelines booklet.