Cardiac rehabilitation is a safe and effective way to treat patients who have experienced cardiac events. The aim of the present study is to evaluate the effectiveness of cardiac rehabilitation program on quality of life of patients undergoing heart valves surgeries. Quasi-experimental, pretest – posttest was utilized in this study. A convenience sample of sixty adult male and female patients .The first tool " Patient's health need assessment sheet " second tool " German version of the Short-Form Health Survey (SF-36)." Results concluded that; All subscales scores of the SF-36 survey was shown to have a significant increase after application of cardiac rehabilitation program. Conclusion: Providing written program for patients was much more effective on improvement health-related quality of life of patients undergoing heart valvular surgeries. Recommendations: a nurse rehabilitator is of great value in both cardio thoracic surgery department and the out-patient clinic and a rehabilitation program are of great importance for the cardiac patients.