Aim: to assess self care behavior of patients with heart failure, design suggested nursing guidelines for patients with heart failure. Subjects and methods; The study was conducted in the internal medicine department and cardiac clinic at Assiut University Hospital. A convenience sample of 60 adult patients with congestive heart failure grade I, II, III from both males and females aged between (18-65) years old were included in this study. Tools; Tool (1) patient assessment sheet and Tool (2) Heart Failure Self-Care behavior Scale. Results; The findings revealed that the majority of patients aged between (41-60) yrs old, regarding to patient's knowledge, (60%) of patients had unsatisfactory level of knowledge, there was a statistical significant relation between self care behavior and knowledge. Conclusion; Based on findings of the present study, it can be concluded that, patients were not adherent to self care behaviors; Socio demographic characteristic had clear effect on the knowledge of the patients. Also, the study concluded high percentage from patients had poor knowledge which affected on patients self care behavior; results of this study could be useful for the development of nursing interventions that can promote/improve self-care in this population. Recommendations: Health education including the suggested nursing guidelines for patients with congestive heart failure is mandatory to improve self care behavior.