Paracentesis defined as remove excess fluid from the abdominal cavity. The aim of the study: assess nurses'
knowledge about paracentesis, design and implement nursing guidelines about paracentesis for nurses, evaluate the effect of designed nursing guidelines on nurses' knowledge about paracentesis and to evaluate patient's complications after applying designed nursing guidelines. Research design: A quasi-experimental research design was utilized on a convenient sample of 30 nurses and 60 patients divided in two group (study and control group), (30) for each. The study was conducted in internal medicine unit, radiology unit and intermediate care unit of Al-Rajhy Liver Hospital. Tools: a) Questionnaire sheet. b) Patients' complications assessment sheet. Results: a good improvement in the mean knowledge scores were found after the implementing of designed nursing guidelines (39.43±7.73 post and 61.5±5.46 pre) with a statistically significant difference and the complications of paracentesis were lesser among study group patients about (33.3% in the study group and 83.3 in the control group). Conclusion: patients undergoing paracentesis exposed for several complications. Improving nursing guidelines can favorably affect the incidence of these complications. Recommendation: Continous training programs to improve their knowledge which will reflect into their practice.