Municipal Waste Workers in waste management operations are the primary affected population at risk of exposure to waste hazards. This study aimed to: Assess the prevalence of occupational health hazards and safety measure among Municipal waste workers at Assiut city. Subjects &Methods: Descriptive research design was utilized. The convenience sampling was used; the total number (400) workers. Data were collected by utilizing two tools; First tool: Demographic questionnaire Sheet Second tool: An Observational Check List for practice of municipal waste workers. Results: Presented that 40.5% of the workers aged more than 50 years, while 27.0% less than 40 years. Also 70.7% of the workers were exposure to injury during work. While 93.7% of workers don't use personal safety measures. Only 25.25% of the studied sample had good knowledge. Conclusion: More than one third of the workers had poor knowledge about occupational health hazards and not applies safety measures practice. Recommendations: Educational program for workers to improve their knowledge and practice about occupational hazards and personal protective equipment