Background: Breast and gynecological cancer are the most common type of cancer in women and need rehabilitation programs to improve QOL. Aim of the study was to assess the effectiveness of nursing intervention program on QOL improvement in women undergoing treatment for gynecological and breast cancer. Study design: A quasi experimental study design. Sample and settings: A randomly selected sample of 100 women diagnosed with gynecological and breast cancer who attended the oncology institute, and divided to two groups, the study group and control group. Tool structured interview questionnaire included socio-personal data, oncology treatment side effects record, reproductive concerns scale, female sexual function index, impact of event scale" cancer specific stress", and functional assessment of cancer therapy-general. Results: Quality of life of the intervention group with breast and gynecological cancer have been improved under the influence of the nursing intervention program. Conclusion and Recommendations: The nursing intervention program showed evidence of improved QOL, with a reduction in the sexual dysfunction, and lower stress levels. It was suggested to heighten awareness about the breast and gynecological cancer treatment-related side effects among the nursing staff.