Premenstrual syndrome is a debilitating condition, causing social and occupational impairment in the lives of affected women. Aim: evaluate the premenstrual syndrome and quality of life among Sohag University female students. Subjects & method: The study was carried out in six faculties which had been selected randomly from Sohag University. Design: A descriptive correlational design was utilized in this study. Sample: The study sample included all available single female students in the selected faculties at Sohag University experienced premenstrual syndrome. Tools of data collection: Three tools were used; demographic data sheet, premenstrual syndrome questionnaire and women's quality of life questionnaire. Results: Results revealed that, the mean age of studied students was19.9+1.4. The majority of them (81.9%) were from rural areas. It was found that, 61.2% of female students experienced low PMS & 38.8% of them experienced severe PMS. Conclusion: The study concluded that, more than one-third of the sample experienced severe premenstrual syndrome. Also, premenstrual syndrome was positively significantly correlated with all domains of quality of life as well as the total score of quality of life. Recommendation: The study recommended that, psycho-educational program is essential to decrease the severity of premenstrual syndrome among students and enhance their quality of life.