Aim of the study:1] To assess nurses' knowledge and practice regarding percutaneous nephrostomy tube patients, 2]To develop postoperative care standards for nurses dealing with percutaneous nephrostomy tube patients 3]To identify percutaneous nephrostomy tube patient' needs Subjects and method: Descriptive exploratory study was utilized on a sample of 16 nurses, 14 physician and 30 patients aged from 18-65 years from both sexes. This study was conducted in the urology department at Assiut University Hospital. Tools: utilized for data collection were a] Questionnaire sheet. B] Observation checklist sheet. C] Postoperative basic nurses' competencies opinionnaire sheet. D] Patient assessment sheet. Results: showed that; half of nurses had poor knowledge regarding post operative nursing care standards for percutaneous nephrostomy tube patients. Nurses showed that inadequacy in their practice. The majority of physicians and nurses had agreed as regard the basic nursing competencies for post-operative percutaneous nephrostomy tube patients. Conclusion: percutaneous nephrostomy tube patients exposed to several complications. Improving nurses` knowledge and practice can favorable decrease the incidence of these complications. Recommendations: Nurses should be aware by postoperative complications and how to prevent them. Nurses in need for in-service training programs and refreshing courses to improve their knowledge which will reflect on their practice.