Intracranial surgery means surgery performed inside skull to treat problems in brain and surrounding structures. This study aims to: determine physical, social and emotional problems of patients after intracranial surgery, identify needs of patients after intracranial surgery and develop and implement nursing educational program based on patient`s needs. Hypotheses: Studied participants patients post application of nursing educational program will exhibit more knowledge, health improvement and fewer complications. Subjects and methods: Sixty adult patients after intracranial surgery (burr hole, craniotomy and craniectomy). Their age 18-65 years old, fully conscious, both sexes. Patients divided randomly into two groups; control group (30 patients received routine care) and study group (30 patients received nursing educational program).Two tools were used for data collection; patient assessment sheet and patient evaluation sheet. Research design: Quasi- experimental research design. Results: Good improvement in total knowledge scores of study group patients after application of program. Majority of patients in study group showed health improvement while less than half of patients in control group showed health improvement. Conclusion: Improving patients` knowledge in study group had a favorable effect in improving their health than in control group. Recommendation: Establishment of educational center in neurosurgery department to educate patients about their conditions