Depression, anxiety, stress and poor quality of life are often psychological consequences of living with cancer. This study aimed to assess psychological symptoms and Quality of life among patients with colorectal cancer. A descriptive research design was used to assess patients diagnosed as colorectal cancer. The study was carried out at outpatient clinic of the oncology department at Assiut University Hospital and South Egypt Cancer Institute. Four tools were utilized to measure the variables of the study; the demographic data questionnaire, socioeconomic status scale, Quality of life (QOL) scale and Symptoms Check List (SCL-90-Revised). Results of the study: Females more than males. Most of the patients were living in rural areas , the vast majority of studied group were at middle level of socioeconomic status and have moderate quality of life most of them have cancer colon, (47.6%) of patients have loss of appetite, (64.2%) of them have weight loss and didn't have colostomy. (39.7%) of them have received chemotherapy. A little high percent of patients have somatization and hostility .The study recommend that: liaison psychiatric nurse should be available to deal with psychiatric problems of patients.