Student nurses are often exposed to various infections during their clinical education. Knowledge and compliance with standard precautions is essential to prevent hospital associated infections and protect patients as well as medical workers from exposure to infectious agents.This study aims:- To assess the knowledge and degree of compliance regarding standard precautions among Nursing Students in Mosul University.Method:- Descriptive Correlational design was applied in the present study. Random sample consist of (158) students' nurses ( Male and Female ) were studied in College of Nursing_ University of Mosul. Data were collected over a period of one month from first February 2014 to first March 2014.Results:- The study indicated that nursing students Knowledge and Compliance with Standard Precautions were high and there is a significant relationship between nurses Knowledge and Compliance of Standard Precautions.Conclusion and Recommendation:-As a results of this investigation it was concluted that the level of knowledge and compliance of standard precautions among the nursing student is rather high and teaching must be strengthened, particularly with respect to the concepts of nosocomial infection and hand hygiene where students scored less and the Periodic and continuous education program for nursing students about nosocomial infection, and standard precautions as well as further and nation-wide studies can be conducted on a large sample size of nursing student for include all colleges of nursing in Ira.