Colorectal surgery is associated with sizeable morbidity and, for emergency surgery, considerable mortality. Clinical pathways ensure consistency in the management of patients by their streamlined approach to patient care. Aim: The present study aimed to determine the effect of the development of clinical pathway on post-operative complications for colorectal surgery patients. Materials: A quasi- experimental research design was utilized to fulfill the aim of this study. Data were collected from general surgery department and cancer institute at Aswan governorate. Sample: Patients admitted in general surgery department who had undergone colorectal surgery 60 patients were included in the study (30 patients in the study group and 30 patients in the control group), the mean age of the study group and control group was (52.1+6.5 & 49.7+4.7) years respectively. Tools: (1) Perioperative colorectal surgery patient assessment, (2) Clinical pathway variances assessment. Conclusion: Significant difference was observed between study and control group as regard hospital length of stay also significant difference was found between the study and control groups in relation to occurrence of postoperative complications. The study Recommended that, colorectal surgery clinical pathway be used rather than the traditional delivery of care