Aim: determine the educational needs of patients with coronary artery stent, design a nursing educational protocol, and evaluate the impact of implementing the nursing educational protocol on patient's knowledge, and prevention /reduction of complications. Methods: the study was conducted in catheterization Lab at Assiut University Hospital. A convenience sample all adult and mentally competent male and female (60) patients. Tools utilized to collect data were Patient assessment, Pre-Post test questionnaire & Patients Complications assessment. Results: As regard to the mean knowledge scores of post educational protocol: There is a significant improvement of all parameters in response to the given information among the study sample with a percentage (100%) in comparison with the control sample that still have poor knowledge score. As regard to Health promotion of participants: there is no significant statistical differences between control and study samples in relation to local and circulatory complications immediate post and after 3 months. Conclusion: Application of teaching protocol when dealing with coronary artery stent patients shows a significant improvement in Patient's knowledge. Recommendations: Equip the cardiac catheterization unit with simply illustrated guidelines protocol covering PCI Procedure and coronary stent knowledge pre/post cardiac catheterization.