Background: In the era of Direct Acting Antiviral Drugs (DAAs) for Hepatitis C virus (HCV) management, nursing role and their effect on outcome is still underestimated. Aim of the work: Therefore, this study aimed to evaluate the effect of nursing intervention on outcomes for cirrhotic patients receiving DAAs. Patients and method: Quasi –experimental research design was used to conduct this study and designed at the Unit of Treatment of Viral Hepatitis at Assiut Health Directorate to enroll patients with HCV infection and eligible for treatment with DAAs (n=30) and were subjected to nursing knowledge evaluation tools. Two types for tools were applied; Tool (1) patient assessment sheet and Tool (II): (Nursing intervention sheet). Another control group (n=30). Tools were applied in 3 phases; preparatory, implementation and evaluation phase, both pretreatment and post treatment over a six months period. Results: the majority of patients of both study groups were males, farmers, illiterate, and came from rural areas with statistically significant difference. The majority of study group (96.6%) had unsatisfactory knowledge scores regarding knowledge of hepatitis C ,nutrition and treatment, while (67.6%) had satisfactory after implementation of the nursing intervention. Conclusion: The nursing intervention had statistically significant beneficial effects on improving patient's outcomes Recommendation: Providing training program and replication of this study on larger probability sample is highly recommended.