Background: Incentives play an important role in organizations as it influences a variety of work-related behavior, as well as the motivation of employees. Aim of the study: The present study was conducted in the main Assiut University Hospital to assess nurse's perception about the incentives system. Subject sand Methods: This study included 271 nurses who randomly selected from all units at the main Assiut University Hospital. The study included both quantitative and qualitative methods for data collection. Results: High percent of the participants reported that the most important incentives are fair remuneration, bounces, appropriate working hours, and different services (health/ education). The promotion, appreciation of work efforts, a good relations with colleagues and superior encouragement were the most important morale incentives. This is confirmed by the results of Focus group discussions as about half of the participants especially female nurses considered the morale incentives are more important than the financial one especially the good dealing and the respect from the physicians. Conclusion and Recommendations: In conclusion, this study indicates that nurses know what they want from incentives. Attention to priorities and flexible incentives system may help to create the cohesive work environment that nurses seek. Determine the objectives are the most important factors to increase the effectiveness of the incentive system.