Background: Video-assisted thoracoscopic surgery (VATS) is a minimally invasive surgical technique used to diagnose and treat problems in chest. This study aimed to assess the effect of educational nursing protocol on minimizing patients' complications after thoracoscopic surgery. Researsh design: Quasi experimental research design was used to conduct this study. The sample was consisted of a convenience sixty adult patients undergone thoracoscopic surgery. The following tools were utilized for data collection: An interview questionnaire sheet for patients, assessment sheet of patients' knowledge and practice, and assessment sheet for patients' complications. Results: There was highly statistical significance difference between study group patients pretest and posttest in total knowledge and practice after implementation of educational nursing protocol. There was no statistical significance difference between both groups as regard complications. Conclusion: There were improvements in total knowledge and practice after protocol implementation. Wound infection and pain were the only complications happened and with higher percentages in control group than study group. Recommendations: Educational nursing protocol should be given for patients in the form of video to be more understandable