Background: Hepatic encephalopathy is a neuropsychiatric complication associated with liver cirrhosis. It occurs in up to 80% of patients with cirrhosis. Aim: To evaluate effect of nursing teaching guidelines on patients' knowledge regarding minimizing hepatic encephalopathy. Research design: Pre/post-test research design was utilized. Setting The study was conducted at Tropical Medicine and Gastroenterology department at El - Rajhi liver Hospital. Subjects and Methods: Thirty adult patients with liver cirrhosis. Tool: Structured interview questionnaire was utilized for data collection with three parts (sociodemographic, medical data and pre/post knowledge questionnaire). Results: The present study revealed that there was a highly statistically significant difference in the level of knowledge before, immediately post and after three months from application of nursing teaching guidelines. There was no statistically significant relation was documented between patient's knowledge and occurrence of hepatic encephalopathy, ascites and bleeding after three months from application of nursing teaching guidelines. Conclusion: It was concluded that level of knowledge regarding minimizing hepatic encephalopathy was improved after application of the nursing teaching guidelines. Recommendations: A written teaching guidelines hand book in simplified term should be available and distributed for cirrhotic patients about preventive measures of hepatic encephalopathy.