Occupational health and safety is an important issue because of high rates of associated morbidity and mortality of exposed workers to occupational hazardous. Aim: This study aimed to assess workers' knowledge about Occupational Health Hazard in Tiles Factories at Assiut Governorate .Research design: Descriptive cross-sectional research design was carried out in this study. Setting: The study was carried out in tile factories at Assiut Governorate. It included four (4) industrial cities namely: Arab El Awamer city in Abnoub El_Safa city in BinyGhalib, El_Zrapy city inAboteg a factory ,Dashlout in Dirout factories. Sample:total coverage sample(400) of workers from the previous setting.Tools of the study:-Interview questionnaire sheet which developed by researcher after reviewing the relevant literature .Results:Finding revealed that 58.3% of the studied sample have poor knowledge about occupational health hazards in tile factories There were statistical significant difference between the total score of the studied sample knowledge about occupational health hazardous and studied sample age, marital status, level of education Conclusion: More than half of the studied sample have poor knowledge about occupational health hazards in tile factories. Recommendation:The study recommended that, Provide education &training programs should be carried out regularly, special for using of personal protective equipment.