Critically ill patients require mechanical ventilator that also need for sedation. Sedative infusions are associated with several disadvantages, so the implementation of daily interruption of sedation was suggested, nurses should closely monitoring sedation and level of consciousness to minimize these complications. Aim: This study was carried out to evaluate the effect of daily interruption of sedation on level of consciousness among mechanically ventilated patients. Design: a quasi-experimental design. Setting: In ICUs at Assiut university hospital. Subjects: A convenience sampling of 60 adults patients. Sample was assigned to two equal groups (study and control). Tools: Two tools were utilized to collect data of study, tool I: Patient assessment sheet. Tool II: Sedation assessment tool. Method: The researcher used preparatory, implementation and evaluation phases to implement this study. Results: This study revealed that there was a gradual improvement every day in duration of interruption that led to improve ment in the levels of sedation and consciousness among study groups rather than control groups. Conclusion: implementing daily interruption of sedation improve level of consciousness among mechanically ventilated patient. Recommendation Provide in-service education and training program for critical care nurses regarding applying daily interruption of sedation.