Quality of sleep is the satisfaction of sleep experience, integrating aspect of sleep initiation, sleep maintenance, sleep quantity, refreshment upon awakening and a well -recognized predictor of physical and mental health. This study aimed to assess quality of sleep in hemodialysis patients. Research design: This study is Descriptive research design. Sample: A convenience samples of (60) adult patients among regular hemodialysis, their age range between (20 - 60) by Mean ± SD 39.48±11.75from both sexes and are willing to participate in the study. Setting: The study was conducted in Hemodialysis unit at Assiut University Hospital. Tools: Two tools were used: structured interview questionnaire and Sleep Quality Scale. Results: There were severe sleep disorders in hemodialysis patients. Conclusion: sleep affected by many factors that effect on quality of sleep in hemodialysis patients. Recommendations: In addition to medical treatment to eliminate sleep problems and increase their sleep quality, the implementation of sleep hygiene intervention could also be beneficial .Further researcher should focus on identifying new methods and treatments technique to improved sleep quality.