A greenhouse experiment was carried out to assess the potential of the cyanobacterium, Spirulina platensis, yeast, Saccharomyces cerevisiae and two organic amendments namely, molasses and yeast extract singly or integrated for the management of root-knot nematode, Meloidogyne incognita on soybean. Results revealed that soil drenched with S. cerevisiae outperformed S. platensis in promoting plant criteria i.e. plant length, shoot and root weights and total plant fresh weight and reducing nematode parameters in terms of total nematode population and root galling. A synergistic impact on plant and nematode characters resulted in the combination of S. cerevisiae and S. platensis. However, the beneficial effect ofboth S. platensis and S. cerevisiae increased with the introduction of molasses to soil recording 96.6, 91.3 and 92.3% reduction in nematode population, number of females and galls, respectivelyas well as 14.8 and 261.1% improvement in plant length and total plant fresh weight, respectively. Meanwhile,integration of cyanobacterium with organic amendments (yeast extract and molasses) recorded the highest significant (P≤0.05) values of chlorophyll A and B, nitrogen, phosphorus and potassium. The present findings suggest that soil application with both S. platensis and S. cerevisiae as well as organic amendments could be environmental safe, cost-effective and promising alternative of nematicides against M.incognita.