The root-knot nematodes (Meloidogyne spp.), cause great losses in tomato crops. The available measures for managing root-knot nematodes are limited. The growers are mostly depending on synthetic nematicides which have environmental and healthy defects. Thus, alternative approaches are needed to manage plant parasitic nematodes and reduce the adverse impacts of synthetic nematicides. In this study, two pot trials were conducted to evaluate the potential of fluopyram, abamectin and Trichoderma album, as well as their mixtures on the reproduction of the root-knot nematode, Meloidogyne incognita on tomato plants. The obtained results showed that all applied treatments significantly suppressed soil population, mature females, root-galls/root systems, eggs/egg mass and egg masses/root system significantly during both experiments. The co-toxicity factor for the combinations of either fluopyram or abamectin with T. album recorded additive interaction impacts on the reduction of soil population. However, the growth of tomato plants such as total fresh weight, shoot height and root length were increased significantly.