An effective control strategy is needed to avoid the counteract effect of Salmonellosis and Colibacillosis which are considered the major bacterial diseases worldwide that cause heavy economic losses in the poultry industry. This study provides the vital therapeutic role and histopathological view of probiotic treatment on broiler chickens infected with Salmonellosis and Colibacillosis in the liver and intestine. One hundred and fifty- one-day-old SASO broiler chicks of a mixed sex were divided into five groups thirty chicks each, 1st group is a negative one, 2nd group is infected with E.coli (O78), 3rd group is infected with E.coli (O78) then treated with probiotic, 4th group is infected with S. Typhimurium and the 5th group is infected with S. Typhimurium then treated with probiotic through two delivery system (food and water) for 5 consecutive days and the experiment lasted for four weeks. Necrotic and hemorrhagic hepatitis and catarrhal enteritis were the most pathological findings with both pathogens. In probiotic treated groups the previous pathological findings were significantly decreased. In addition, the probiotic treated group showed improvement of body weight gain, feed intake, and lower feed conversion ratio (FCR) compared to the infected groups. From the previous results, we elucidate the commercial feasibility and the prophylactic potency of probiotics in the future of the broiler industry especially because of its constancy during storage, processing, and delivery mechanism.