This study was conducted to determine the prevalence, clinical picture, complications, and risk factors associated with Diabetes Mellitus in dogs in Alexandria governorate, Egypt. One hundred and thirty-nine dogs representing fifteen breeds from the Directorate of Veterinary Medicine in Alexandria governorate were involved in the study between November 2020 and April 2021. After a thorough clinical examination and filling out a pre-designed questionnaire, random blood glucose (RBG) test was performed for all animals. Those with high RBG levels were subjected to a complete blood picture (CBC), liver and kidney functions, and HbA1c. A control group of 50 dogs of similar age, sex, breed, and management was selected and subjected to the same analyses. The prevalence of DM among the studied dogs was 7.2 %. All diabetics suffered from polydipsia and polyuria, while 60% suffered from polyphagia and 80% suffered from weight loss. No significant impact of DM on temperature, respiratory rate, anaemia, liver enzymes and platelets count, but there was a significant increase in pulse rate. There was a significant impact of DM on eyes as 80% of the diabetic dogs suffered from cataracts. It had a significant impact on total leucocyte count and on the renal function, where 70 % of the diabetics had impaired renal functions. Regarding the risk factor analysis associated with the occurrence of DM, only breed has been identified as a potential risk factor for cDM (canine diabetes mellitus). So, a spotlight must be thrown on cDM as an essential and not uncommon dog's disease, and we need to raise awareness of cDM among veterinarians and dogs' owners.