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272404

Clinico-Pathological Studies on <i>Helicobacter pylori</i> Infection in Albino Rats

Article

Last updated: 24 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Veterinary pharmacology

Abstract

Helicobacter pylori (H. pylori) is known to be the most common agent in peptic ulcers and chronic gastritis. The goal of this study was to investigate how H. pylori infection affect several hematological and biochemical parameters. To achieve this goal, thirty albino male rats were divided into three groups for challenge with H. pylori Ag. Two groups were daily fed on H. pylori suspensions in food and water, whereas the third group was kept as a control group. Serum iron, ferritin, copper (Cu), zinc (Zn), magnesium (Mg), lipid profile, SGPT (ALT), SGOT (AST), and full blood picture were all measured at day 90 (the end of the experiment). The findings demonstrated that H. pylori stool Ag was present in the feces of infected rat groups and was elevated throughout the trial. Antibodies against H. pylori have increased in serum. Hematological and biochemical markers, particularly iron and ferritin, as well as hemoglobin and leukocytes, were all negatively affected. In addition, all signs of gastric inflammation were demonstrated among the infected groups. Overall, after exposure to H. pylori infected food and water, numerous haematological parameters were disturbed and seriously impacted various organs. 

DOI

10.21608/djvs.2022.146381.1082

Keywords

Helicobacter pylori, iron, Ferritin, Copper, Zinc, magnesium, ALT, AST

Authors

First Name

Essaa

Last Name

Ghobashi

MiddleName

AA

Affiliation

Pathology Department, Faculty of Veterinary Medicine, Damanhour University, Damanhour-22511, El-Beheira, Egypt

Email

ghobashiesraa@gmail.com

City

-

Orcid

-

First Name

Hoda

Last Name

Abd-Ellatieffb

MiddleName

A

Affiliation

Pathology Department, Faculty of Veterinary Medicine, Damanhour University, Damanhour-22511, El-Beheira, Egypt

Email

dr_hodaha@yahoo.com

City

Damanhour

Orcid

-

First Name

Wael

Last Name

Goda

MiddleName

M

Affiliation

Pathology Department, Faculty of Veterinary Medicine, Damanhour University, Damanhour-22511, El-Beheira, Egypt

Email

waelgoda2010@yahoo.com

City

Damanhour

Orcid

-

First Name

Rania

Last Name

Hamada

MiddleName

-

Affiliation

Pathology Department, Faculty of Veterinary Medicine, Damanhour University, Damanhour-22511, El-Beheira, Egypt

Email

rania.hamada@vetmed.dmu.edu.eg

City

-

Orcid

-

First Name

Abdel-Rahman

Last Name

Abou-Rawash

MiddleName

-

Affiliation

Pathology Department, Faculty of Veterinary Medicine, Damanhour University, Damanhour-22511, El-Beheira, Egypt

Email

rawashaa@yahoo.com

City

Damanhour

Orcid

-

First Name

Shahinaz

Last Name

Hassan

MiddleName

M. H.

Affiliation

Animal Health Research Institute (AHRI) Agricultur Research Center (ARC), Alexanderia regional Lab., Alexanderia, Egypt.

Email

eshahenaz12@yahoo.com

City

Alexandria

Orcid

-

Volume

9

Article Issue

1

Related Issue

38024

Issue Date

2022-12-01

Receive Date

2022-06-22

Publish Date

2022-12-01

Page Start

1

Page End

6

Print ISSN

2636-3003

Online ISSN

2636-3011

Article File

DJVS_Volume 9_Issue 1_Pages 1-6.pdf

PDF . 669.8kB

Link

https://djvs.journals.ekb.eg/article_272404.html

Detail API

https://djvs.journals.ekb.eg/service?article_code=272404

Order

272,404

Type

Original Article

Type Code

1,001

Publication Type

Journal

Publication Title

Damanhour Journal of Veterinary Sciences

Publication Link

https://djvs.journals.ekb.eg/

MainTitle

Clinico-Pathological Studies on <i>Helicobacter pylori</i> Infection in Albino Rats

Details

Type

Article

Created At

22 Jan 2023