The present research was aimed to detect the deleterious effects of lead on the biochemical, histopathological, and reproductive performances of Newzealand rabbit and Yucca schidigera extract role in protecting the tox impacts. sixty mature male Newzealand rabbits were divided into four groups, each one subdivided into 3 replicates. The treatments as follows: group 1 control basal diet, group 2 basal diet + 150 mg Pb/kg bwt, group3 basal diet +yucca (100 mg/kg diet), and group 4 basal diet + Pb (150 mg Pb /kg diet) + yucca (100 mg/kg diet). lead exposure group showed decreasing sperm concentration, and motility in comparison with control, and adding yucca extract can improve reproductive performance concerning control. Aspartate aminotransferase, alanine aminotransferase, creatinine, and uric acid were significantly elevated in Pb while, yucca treated groups and co-exposure to yucca with Pb were significantly decreased than the lead alone group. Pb-exposed group significantly decreased total antioxidant capacity, superoxide dismutase activities and reduced glutathione content, and significant elevation in malondialdehyde and nitric oxide. Co-exposure to yucca with lead elevate the antioxidant parameter and reduced MDA and NO than lead alone. Co-exposure to yucca+ Pb reduced the level of Pb residues in hepatorenal tissue than the lead-exposed group. The results of adding yucca exhibited have a protective effect against the lead-induced inhibitory effects on biochemical and reproductive performances of rabbit and yucca have improved the toxic impacts induced by lead in rabbit