The present study was aimed to evaluate anesthetic properties, clinic-physiological and hemato-biochemical effects of propofol alone, thiopental alone or propofol/thiopental mixture in dogs with experimental liver insufficiency. For this purpose, 9 apparently healthy male dogs exposure to electrocauterization to induce liver insufficiency model.   The dogs were randomly divided into three groups; each group consists of three dogs.  All dogs were premedicated with Xylazine Hcl (1mg/kg bwt/i.m). The induction of general anesthesia was done via i/v injection of 6 mg/kg bwt Propofol (group A); 5mg/kg bwt Thiopental (group B) and 3 mg/kg Propofol + 2.5 mg/kg Thiopental mixture (group C). Blood samples were collected from the three groups at15mins before anesthesia induction then at 15, 30 and 45 minutes after treatments for both clinico-physiological and hemato-biochemical evaluations. A mild alteration in some physiological parameters and hemato-biochemical values was observed after anesthesia induction in all groups, but it still safe induce general anesthesia in dogs affected with liver insufficiency. However, Propofol /Thiopental mixture was induced a rapid, smooth induction and a longer duration of anesthesia with complete muscle relaxation which is suitable for all most surgical operations.