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53159

Evaluation of the in vitro and in vivo inhibitory effects of quercetin on the growth of Babesia and Theileria parasites

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Last updated: 04 Jan 2025

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Abstract

Quercetin has antioxidant, anti-inflammatory, antitrypanosomal, and antimalarial activities. The hindering properties of quercetin were appraised for three Babesia species and Theileria equi in vitro and against Babesia microti in mice. Quercetin exhibited substantial growth restraint for Babesia bovis, Babesia bigemina, Babesia caballi, and Theileria equi with IC50 values of 8, 7, 5, and 4 nM, respectively. T. equi growth was suppressed at 50 μM concentration. Parasite regrowth was repressed in the consequent viability test at 100 μM for Babesia bovis and Babesia bigemina and 50 μM for Babesia caballi and Theileria equi. Quercetin at a dose rate of 14.5 mg/kg raised a 77.5 % reticence of Babesia microti progression in BALB/c mice. Quercetin might be of value as a treatment in babesiosis and theileriosis.

DOI

10.21608/djvs.2019.53159

Keywords

Quercetin, Babesia, Theileria equi, in Vitro, in vivo

Authors

First Name

Mahmoud

Last Name

AbouLaila

MiddleName

-

Affiliation

Department of Parasitology, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, El-Behera, Egypt

Email

hethet2004@yahoo.com

City

-

Orcid

-

First Name

Amer

Last Name

Abdelaziz

MiddleName

-

Affiliation

Department of Parasitology, Faculty of Veterinary Medicine, Sohag University, Sohag82524, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Rizk

MiddleName

-

Affiliation

Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt

Email

-

City

-

Orcid

-

First Name

Rehab

Last Name

Mady

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, El-Behera, Egypt

Email

-

City

-

Orcid

-

First Name

Naoaki

Last Name

Yokoyama

MiddleName

-

Affiliation

Department of Disease Control, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido

Email

-

City

-

Orcid

-

First Name

Ikuo

Last Name

Igarashi

MiddleName

-

Affiliation

Department of Disease Control, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido

Email

-

City

-

Orcid

-

Volume

2

Article Issue

1

Related Issue

7432

Issue Date

2019-09-01

Receive Date

2019-09-21

Publish Date

2019-10-05

Page Start

23

Page End

27

Print ISSN

2636-3003

Online ISSN

2636-3011

Article File

DJVS_Volume 2_Issue 1_Pages 23-27.pdf

PDF . 492.0kB

Link

https://djvs.journals.ekb.eg/article_53159.html

Detail API

https://djvs.journals.ekb.eg/service?article_code=53159

Order

5

Type

Original Article

Type Code

1,001

Publication Type

Journal

Publication Title

Damanhour Journal of Veterinary Sciences

Publication Link

https://djvs.journals.ekb.eg/

MainTitle

Evaluation of the in vitro and in vivo inhibitory effects of quercetin on the growth of Babesia and Theileria parasites

Details

Type

Article

Created At

22 Jan 2023