Sustainable purchasing has become an important interest in the world because purchasing decisions can have environmental and social effects, particularly for hotels sector. Hotels can generate a number of benefits by implementing sustainable purchasing but there are several challenges facing its implementation. Therefore, this study aimed to identify challenges of implementing sustainable practices in purchasing process management. The study chooses a case study to explore the challenges of implementing sustainable practices in purchasing process management. The study used structured interview to collect data. The population of study is 35 respondents consist of purchasing managers; stores managers; food and beverage managers; food and beverage cost controllers; and executive chefs in one of the five-star hotel chain in Cairo which including 7 hotels. The data collected was analyzed by SPSS version 26. The result revealed that there is a significant and positive effect between the implementation of sustainable practices and the benefits of implementing sustainable practices in purchasing process management and there is a significant and negative effect between the implementation of sustainable practices and the challenges of implementing sustainable practices in purchasing process management.