The research seeks to identify the role of entrepreneurial orientation in achieving competitive advantage in Egyptian hotels by using a questionnaire form as the main tool for collecting primary data and directed to a random sample of employees in the hotels under study. The data obtained were analyzed using SPSS V23. The results showed that a variation in the relative importance of the dimensions of the entrepreneurial orientation and competitive advantage in hotels. There is a significant correlation between it; entrepreneurial orientation had a positive effect on achieving competitive advantage. The research recommends hotels to apply the concept of entrepreneurial orientation to achieve competitive advantage through continuing to provide adequate support for creative activities, working to implement new ideas that would meet the needs and desires of customers; encouraging the hotel management staff to engage in activities that exhibit a high degree of risk, allowing them to experiment, and giving them opportunities to learn from their mistakes.