The study aimed to assess the impact of some variables (strategic leadership, empowerment, organizational culture, psychological capital, and managerial creativity) on talent management, as well as the effect of adopting talent management on some variables (human resource agility, organizational ambidexterity, competitive intelligence, organizational sustainability, organizational reputation, and smart organizations) while exploring the mediating role of some of these variables. To achieve the aim of the study; 600 questionnaires were distributed to a sample of employees in travel agents – Category A - in Cairo, while 482 questionnaires were analyzed using SPSS V.26 and AMOS V.25. The results concluded that empowerment and organizational culture play a partial mediating role in the relationship between strategic leadership and talent management, while managerial creativity plays a fully mediating role in the relationship between psychological capital and talent management. The results also confirmed that organizational ambidexterity plays a partial mediating role in the relationship between talent management and competitive intelligence and that human resource agility plays a partial mediating role in the relationship between talent management and organizational sustainability.