Given that work stressors affect hotels profitability, this study aims at assessing the role of human resource management in handling work stressors. Sharm El-sheikh city was selected for the survey, 21 hotels as a random sample participated in the survey. A questionnaire form was distributed among a sample of hotels employees to evaluate the level of work stressors among them, in parallel HR managers of these hotels were interviewed to assess their efforts in handling these stressors. A high level of work stressors were detected among the employees, HR activities simultaneously were not effective enough to handle the stressors. The study recommends relevant solutions to overcome this problem.