This study compared the productive and economic performances of two shrimp species, Litopenaeus vannamei (L. vannamei) and Fenneropenaeus indicus (F. indicus), on Ghalioun shrimp farms located on Egypt's Mediterranean coast at Kafr El-sheikh Governorate from 2017 to 2019. A total number of ponds were assigned to both species, which were stocked at a rate of 150 Post larvae (PL) /m². The average weight of the shrimp was measured weekly, whereas productive performance parameters such as body weight gain, feed intake, and feed conversion ratio (FCR) were calculated monthly. Additionally, mortality rates were recorded monthly, and an economic study was conducted on the data for three production seasons. Total costs, total variable costs, total returns, and net returns are among the economic parameters calculated. L. vannamei had higher performance growth parameters as well as a lower mortality rate compared to F. indicus, including final body weight/shrimp (36.37 g and 30.44 g), weight gain (32.80 and 27.94 g/shrimp), and FCR (1.8 and 1.9). According to economic analysis, the total variable costs, total costs, total returns, and net profit per 100 shrimp in L. vannamei were 161.3, 176.3, 697.3, and 521 LE, respectively, compared to 152.54, 167.54, 577.60, and 410.06 LE in F. indicus. It was reasonable to conclude that stocking L. vannamei was better at density 150 PL/m² in terms of growth performance, feed efficiency, mortality rate, and economic evaluation under these experimental conditions.