Hyperlipidemia constitutes a major problem causing serious health problems. The current study was conducted to investigate the effect of Pomegranate peel (PC) and Licorice (LC) extracts as anti-hyperlipidemic agents in rats. Sixty male Wister rats were used in current study. They were divided into 6 groups; Group Ι: Control (C), Group ΙΙ: Pomegranate control (PC), Group ΙΙΙ: Licorice Control (LC), Group ΙѴ: Hyperlipidemia control (H), Group Ѵ: Hyperlipidemia pomegranate (HP), Group ѴΙ: Hyperlipidemia licorice (HL). Pomegranate was administrated 200 mg/kg body weight, while licorice was administrated 400 mg/kg body weight. All doses were given by oral gavage. The results showed that pomegranate peel and licorice extract significantly reversed the levels of serum lipid profile, glucose and hepatic damage markers, and antioxidant of hyperlipidemic rats. Histopathological examination of liver tissues was in concurrence with the biochemical results. It is logical to consider that the antihyperlipidemic and antioxidative properties of pomegranate and licorice are mechanistically achieved. So, pomegranate and licorice could be used as protective agents against hyperlipidemia and subsequent resulted metabolic disorders.