Aeromonads are one of the emerging bacterial pathogens commonly found in fresh and brackish water environments, and they have been recognized as primary pathogens to fish for some time. In this study, 108 Aeromonas  species were isolated from diseased Nile tilapia and Mugil sehelii with a total prevalence of 72and M. sehelii fish exhibited the highest percentage of Aeromonas infection (80%) while O. niloticus (62.9%). For A. hydrophila, The highest percent of infection was detected in isolates of O. niloticus with 45.45%, while in Mugil fish, the percentage of infection was 43.75%. For A. sobria,  The highest percentage of infection was detected in isolates of Mugil fish. The percentage of infection with a percent of (56.25%) while in O. niloticus the percentage of infection with A. sobria was 54.54%. The multi-drug resistance(MDR)pattern of recovered isolates revealed 75.9% of the isolates showed resistance to cefaclor and erythromycin. 65.7% showed resistance to Tetracycline and Sulfisoxazole. Resistance to Trimethoprim was detected in 55.5% of the isolates, while resistance to Ciprofloxacin could be detected in 13.9% of the isolates.