Hepatic encephalopathy (HE) is considered as serious clinical complication of acute and chronic liver injury. Previous researches elucidated HE but characterization of neuropathology in different brain  areas is limited .The present study is conducted to evaluate the progression of neuropathological lesions in different brain areas in rat model with liver fibrosis induced by thioacetamide (TAA). For this experiment 20 male rats was divided into two groups control and TAA treated group that was I.P injected twice a week with 100 mg/kg.b.w TAA dissolved in saline for 3 months. Three rats from each group were euthanized after 3 months and the liver specimens were collected for ensuring the development of rat model for liver fibrosis.The remained rats were kept without further treatment with TAA  for 2  months, rats were carfeully monitored for abnormal signs. After the end of experimental period, rats were euthanized and the brains were collected for histopathological examination. Microscopic examination of brain revealed various neurpoathological lesions that varied in severity between different brain areas. The most severe lesions were recorded in midbrain and pons while mild lesions were detected in cerebral cortex and striatum. The brain lesions comprised varied degrees of neuronal degeneration with marked astroglial and microglial reactions in the different brain regions. The obvious inflammatory reaction indicates that the neuroinflammation play an important role in the mediation of HE.