Skin diseases are the most common health problem among dogs. Demodicosis is the most important one. The study aimed to detect the clinical effect of demodicosis on dogs which come to veterinary clinic and the correlation between some blood parameters and some oxidative stress indices. Clinical and laboratory examination of the diseased dogs was carried out. The clinical study was conducted on two groups of dogs. The first one includes seven dogs (7.77%) out of 90 diseased dogs of different ages. The second group 14 dogs were clinically healthy used as a control group. Animals were subjected to physical examination followed by special dermatological examination. Skin scrapings were examined under microscope for mite's detection. Blood samples were taken for hematological examination and biochemical analysis. Hematological parameters of demodicosis affected dogs showed a highly significant decrease in hemoglobin values. Regarding differential leukocytes, a significant increase in granulocytes absolute number was recorded. The biochemical findings of blood plasma obtained from dogs affected by demodicosis showed a significant increase in plasma SOD when compared with control ones and a highly significant increase in plasma MDA values. Correlation analysis revealed positive correlation between plasma zinc and copper levels and antioxidant enzymes as SOD, GPx and negative correlation between plasma SOD and plasma MDA levels. The study revealed the importance of oxidative stress indicators variations in diagnosis and pathophysiology of demodicosis.