In the present study, we evaluated and tested the hypocholesterolemic effect of statin (atorvastatin) in chickens. Thirty six (36) of one day old Cobb chicks were kept for 2 weeks for adaptation then divided into 3 equal groups each (12). Control (Gp.1) did not receive any treatment.GP-2 treated orally with 0.02% atorvastatin (0.2gm/kg ration). GP-3 treated orally with 0.05% atorvastatin ( 0.5gm/kg ration).Serum and whole blood sample were collected from all groups 2nd week and 4th week post treatment to evaluate some hematological and biochemical changes as well as immunomodulatory cytokines TNF-α, IL1β, and IL6. Oral treatment of the atorvastatin caused significant benefit results in chickens appeared in the correction of some biochemical parameters also try to stimulate cytokine response represents in TNF-α, IL1β, and IL6. From the present work, it could be concluded that statin (atorvastatin) has potent hypocholesterolemic effect, this appear in the correction with hematological, biochemical and immunological results.