The rabbit Clostridial enterotoxaemia bloat vaccine has been produced for the first time in Egypt  at Anaerobic Department at Veterinary Serum and Vaccines Research Institute .It was found that this vaccine induced efficient immunity  when it was injected in two doses (4 weeks interval)  as 2ml for adult rabbits and 1ml for offspring as the results of vaccinated rabbit at breeding period was 1 IU/ ml, 3IU/ml, and 1.63 IU/ml by mouse neutralization test, heamolytic inhibition assay, and ELISA respectively.  Also it produced a very good protection  against the disease for 5 months, so animal could be revaccinated after 5 months from primary vaccination. Also during pregnancy booster dose should be given to increase the maternal antibodies titer against the disease, the results of pregnant dams post booster vaccination were 3IU/ml, 7IU/ml, and 3.74 IU/ml which give passive immunity to the newborn till 4 – 6weeks after birth, the titer was 0.5 IU, 1 IU/ml, and 1.17IU/ml one month post parturition.