This study aimed to examine the sensitivity of different antibiotics against 10 Salmonella serovars isolated previously from broiler farms. After that, all resistant serovas were detected genetically for the presence of qnrA, blaTEM, tetA (A) and aadB resistant genes. Two S. Typhimurium, one S. Kentucky, one S. Newport, one S. Tamale, one S. Enteritidis, one S. Molade, one S. Takoradi, one S. Virchow and one S. Inganda were examined sensitivity against different antibiotics by disc diffusion method. The resistant serovars to quinolones, β lactams, gentamycin and doxycyclin were confirmed genetically. S. Kentucky, S. Tamale, S. Molade, S. Typhimurium and S. Takoradi were resistant to quinolones and carrying qnrAgene. S. Tamale, S. Inganda, S. Typhimurium, S. Newport, S. Molade, S.  Typhimurium, S. Enteritidis, S. Takoradi and S. Virchow were resistant to β lactams and carrying blaTEM gene. S.Tamale, S. Inganda, S. Typhimurium, S. Newport, S. Molade, S. Enteritidis and S. Virchow were resistant to doxycyclin  and carrying  tetA (A) gene. S. Typhimurium, S.  Enteritidis and S. Takoradi were resistant togentamycin and carrying aadB gene. The results showed that emerging of multidrug resistant strains to common antibiotics in the poultry field required newly discovered herbal compounds for control the disease and prevent the resistant phenomena.